Secondary Hemostasis: Forming the Blood Clot

Now that the platelet plug is complete, its time for secondary hemostasis to stabilize it. In order to strengthen the weak platelet plug, several coagulation factors and cofactors are required. The stabilization of the platelet plug results in a “coagulation cascade” that ultimately changes the fibrinogen linking the platelets with a crosslinked and more stable …

Primary Hemostasis

The term hemostasis means prevention of blood loss. Normal hemostasis is a consequence of tightly regulated processes that maintain blood in constant movement inside vessels. When a vessel is severed, several cells, factors and cofactors are activated to prevent the continued loss of blood and to repair the damage. Hemostasis is divided into primary and …